RIKEN Center for Biosystems Dynamics Research, Laboratory for Morphogenetic Signaling (Hayashi Lab.)



Original Paper


Net, skin and flatten, ImageJ plugin tool for extracting surface profiles from curved 3D objects

Housei W, Shigeo H.

MicroPubl Biol. 2020 Aug 19;2020:10.17912/micropub.biology.000292.doi: 10.17912/micropub.biology.000292.

ERK signaling dynamics in the morphogenesis and homeostasis of Drosophila

Hayashi H, Yosuke O.

Curr Opin Genet Dev. 2020 Aug;63:9-15. doi: 10.1016/j.gde.2020.01.004.Epub 2020 Mar 4.


Two-step regulation of trachealess ensures tight coupling of cell fate with morphogenesis in the Drosophila trachea.

Kondo T, Hayashi S.

Elife. 2019 Aug 23;8. pii: e45145. doi: 10.7554/eLife.45145.

The plus-tip tracking and microtubule stabilizing activities of Javelin-like regulate microtubule organization and cell polarity.

Baskar R, Bahkrat A, Otani T, Wada H, Davidov G, Pandey H, Gheber L, Zarivach R, Hayashi S, Abdu U.

FEBS J. 2019 Jun 1. doi: 10.1111/febs.14944. [Epub ahead of print]

Nanopore Formation in the Cuticle of an Insect Olfactory Sensillum.

Ando T, Sekine S, Inagaki S, Misaki K, Badel L, Moriya H, Sami MM, Itakura Y, Chihara T, Kazama H, Yonemura S, Hayashi S.

Curr Biol. 2019 Apr 18. pii: S0960-9822(19)30341-0. doi: 10.1016/j.cub.2019.03.043. [Epub ahead of print]

Automated FRET quantification shows distinct subcellular ERK activation kinetics in response to graded EGFR signaling in Drosophila.

Ogura Y, Sami MM, Wada H, Hayashi S.

Genes Cells. 2019 Apr;24(4):297-306. doi: 10.1111/gtc.12679.


Trynity controls epidermal barrier function and respiratory tube maturation in Drosophila by modulating apical extracellular matrix nano-patterning.

Itakura Y, Inagaki S, Wada H, Hayashi S.

PLoS One. 2018 Dec 21;13(12):e0209058. doi: 10.1371/journal.pone.0209058. eCollection 2018.

A Switch-like Activation Relay of EGFR-ERK Signaling Regulates a Wave of Cellular Contractility for Epithelial Invagination.

Ogura Y, Wen FL, Sami MM, Shibata T, Hayashi S.

Dev Cell. 2018 Jun 27. pii: S1534-5807(18)30458-1. doi: 10.1016/j.devcel.2018.06.004. [Epub ahead of print]

Development and Function of the Drosophila Tracheal System.

Hayashi S, Kondo T.

Genetics. 2018 Jun;209(2):367-380. doi: 10.1534/genetics.117.300167.


Size in development.

Hayashi S, Morimoto M, Inomata H, Piccolo S.

Dev Growth Differ. 2017 Jan;59(1):3. doi: 10.1111/dgd.12339. No abstract available.

Shape and geometry control of the Drosophila tracheal tubule.

Hayashi S, Dong B.

Dev Growth Differ. 2017 Jan;59(1):4-11. doi: 10.1111/dgd.12336. Epub 2017 Jan 17. Review.


Escargot controls the sequential specification of two tracheal tip cell types by suppressing FGF signaling in Drosophila.

Miao G, Hayashi S

Development. 2016 Oct 14

IKKε inhibits PKC to promote Fascin-dependent actin bundling.

Otani T, Ogura Y, Misaki K, Maeda T, Kimpara A, Yonemura S, Hayashi S

Development. 2016 Oct 15;143(20):3806-3816

Microtubule-dependent balanced cell contraction and luminal-matrix modification accelerate epithelial tube fusion.

Kato K, Dong B, Wada H, Tanaka-Matakatsu M, Yagi Y, Hayashi S

Nat Commun. 2016 Apr 12;7:11141