RIKEN Center for Biosystems Dynamics Research, Laboratory for Morphogenetic Signaling (Hayashi Lab.)



Original Paper


Dynamic shape changes of ECM-producing cells drive morphogenesis of ball-and-socket joints in the fly leg.
Tajiri R, Misaki K, Yonemura S, Hayashi S.
Development. 2010 Jun;137(12):2055-63.

Dynamic intracellular distribution of Notch during activation and asymmetric cell division revealed by functional fluorescent fusion proteins.
Kawahashi K, Hayashi S.
Genes to Cells Volume 15 Issue 7, Pages 749 – 759 Published Online: 18 May 2010

Evolutionary origin of the insect wing via integration of two developmental modules.
Niwa N, Akimoto-Kato A, Niimi T, Tojo K, Machida R, Hayashi S.
Evolution & Development 2010 Mar;12(2):168-76.


Essential requirement for RING finger E3 ubiquitin ligase Hakai in early embryonic development of Drosophila.
Kaido M, Wada H, Shindo M, Hayashi S.
Genes to Cells Volume 14 Issue 9, Pages 1067 – 1077 Published Online: 13 Aug 2009


Practical guide of live imaging for developmental biologists.
Kato K, Hayashi S.
Development, Growth & Differentiation 2008 Apr 16.

Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis.
Shindo M, Wada H, Kaido M, Tateno M, Aigaki T, Tsuda L, Hayashi S.
Development 135, 1355-1364 (2008)

Conversion of plasma membrane topology during epithelial tube connection requires Arf-like 3 small GTPase in Drosophila.
Kakihara K, Shinmyozu K, Kato K, Wada H, Hayashi S.
Mechanisms of Development Volume 125, Issues 3-4, March-April 2008, Pages 325-336


A wave of EGFR signaling determines cell alignment and intercalation in the Drosophila tracheal placode.
Nishimura M, Inoue Y, Hayashi S.
Development 134, 4273-4282 (2007)

Differential control of cell affinity required for progression and refinement of cell boundary during Drosophila leg segmentation.
Sakurai KT, Kojima T, Aigaki T, Hayashi S.
Developmental Biology Volume 309, Issue 1, 1 September 2007, Pages 126-136

Small peptide regulators of actin-based cell morphogenesis encoded by a polycistronic mRNA.
Kondo T, Hashimoto Y, Kato K, Inagaki S, Hayashi S, Kageyama Y.
Nat Cell Biol. 2007 Jun;9(6):660-5.

Tissue-specific laminin expression facilitates integrin-dependent association of the embryonic wing disc with the trachea in Drosophila.
Inoue Y, Hayashi S.
Developmental Biology Volume 304, Issue 1, 1 April 2007, Pages 90-101

Specialized extraembryonic cells connect embryonic and extraembryonic epidermis in response to Dpp during dorsal closure in Drosophila.
Wada A, Kato K, Uwo MF, Yonemura S, Hayashi S.
Developmental Biology Volume 301, Issue 2, 15 January 2007, Pages 340-349


IKKε Regulates F Actin Assembly and Interacts with Drosophila IAP1 in Cellular Morphogenesis.
Oshima, K., Takeda, M., Kuranaga, E., Ueda, R., Aigaki, T., Miura, M., and Hayashi, S.
Current Biology, Vol 16, 1531-1537.

Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs.
Kuranaga E, Kanuka H, Tonoki A, Takemoto K, Tomioka T, Kobayashi M, Hayashi S, Miura M.
Cell. 2006 Aug 11;126(3):583-96.

An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila.
Tsuda L, Kaido M, Lim YM, Kato K, Aigaki T, Hayashi S.
EMBO J. 2006 Jul 12;25(13):3191-202.

Transcriptional readthrough of Hox genes Ubx and Antp and their divergent post-transcriptional control During crustacean evolution.
Shiga, Y., Sagawa, K., Takai, R., Sakaguchi, H., Yamagata, H., and Hayashi, S.
Evolution & Development 8:5,407- 414

Regulation of Layer-Specific Targeting by Reciprocal Expression of a Cell Adhesion Molecule, Capricious.
Shinza-Kameda, M., Takasu, E., Sakurai, K., Hayashi, S., and Nose, A.
Neuron 49 , 205-213, January 19


Enhancer Trapping With a Red Fluorescent Protein Reporter in Drosophila
Akimoto, A., Wada, H., Hayashi, S.
Developmental Dynamics 233:993-997


Drosophila Nedd4 regulates endocytosis of Notch and suppresses its ligand-independent activation.
Sakata, T., Sakaguchi, H., Tsuda,L., Higashitani, A., Aigaki, T., Matsuno, K., Hayashi, S.
Current Biology 14:2228-2236

Hedgehogand Decapentaplegic instruct polarized growth of cell extensions in the Drosophila trachea.
Kato, K., Chihara, T., Hayashi, S.
Development 131:5253-5261

Formin3 is required for assembly of the F-actin structure that mediates tracheal fusion in Drosophila.
Tanaka, H., Takasu, E., Aigaki, T., Kato, K., Hayashi, S., Nose, A.
Developmental Biology ,274:413-425.


Distinct developmental modes and lesion-induced reactions of dentrites of two classes of Drosophila sensory neurons.
Sugimura, K., Yamamoto, M., Niwa, R., Satoh, D., Goto, S., Taniguchi, M., Hayashi, S., Uemura, T.
Journal of Neuroscience, May1,2003 23(9):3752-3760.

The role of Wg signaling in the patterning of embryonic leg primordium in Drosophila.
Kubota,K.,Goto,S., and Hayashi,S.
Dev.Biol257: 117-126

Rac promotes epithelial cell rearrangement during tracheal tubulogenesis in Drosophila
Chihara,T., Kato,K., Taniguchi,M., Ng,J., Hayashi,S.


GETDB, a database compiling expression patterns and molecular locations of a collection of Gal4 enhancer traps.
Hayashi, S., Ito, K., Sado, Y., Taniguchi, M., Akimoto, A., Takeuchi, H., Aigaki, T., Matsuzaki, F., Nakagoshi, H., Tanimura, T., Ueda, R., Uemura, T., Yoshihara, M., and Goto, S.
Genesis 34:58-61.

Evolving role of Antennapedia protein in arthropod limb patterning.
Shiga, Y., Yasumoto, R., Yamagata, H., and Hayashi,S.
Development 129:3555-3561.


UDP-sugar transporter implicated in glycosylation and processing of Notch.
Goto, S., Taniguchi, M., Muraoka, M., Toyoda, H., Sado, Y., Kawakita, M. and Hayashi, S.
Nature Cell Biology 9:816-822